The University of Patras is located in Patras and in the cities of Messolonghi, Agrinio, Aigio, Pyrgos, Amaliada.

The University campus of Patras (Rion) is located 8 kilometres Northeast of the city of Patras, in the suburb of Rion. It is a self-contained campus at the foot of mount Panachaico with a view over the Gulf of Corinth to the mountains of Central Greece across the water (Map).

The University was initially housed in the centre of Patras. The wooded campus area of about 600 acres was selected in 1968 and was appropriated on behalf of the University. The first buildings of the new University campus were a unit of twenty small ground-level pre-fabricated buildings, which still house some Academic and Administrative offices.

In 1972 the construction of buildings A and B started. Building A houses the administrative services, the Rectorate, the Senate's Conference Hall, the University's Ceremonial Hall, a teaching amphitheatre and a seminar hall. The designing of the campus was entrusted to an internationally known architectural firm. 

Following the master plan, 25 buildings were eventually built, along with a new Library, and many more are under construction for the housing of most of the Departments, a Museum of Science and Technology, a Botanical Garden, a new Student Centre. Within the campus there are also found the Students' Residence Hall, the Conference and Cultural Centre, a Restaurant, a Bank, a Bookstore, the Univesrity's Publishing House, cafeterias and kiosks.

Within the campus there is also the Regional University Teaching Hospital which functions both as the major regional medical centre and as a teaching facility for the Faculty of Medicine.

Concurrently there is a continuous effort to upgrade and improve the landscape within the campus, although extensive infrastructure projects, landscaping and athletic facilities have been completed. Several other facilities are available on campus including a gymnasium, a post-office, a swimming pool, a nursery school, a primary and secondary school for the children of the Academic Faculty and Administrrative Personnel.

In addition to constructing new buildings, new sites at the surroundings have been appropriated on behalf of the University. The campus has many open-spaces, green shady areas covered with characteristically Mediterranean olive groves.